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Animal studies haven't flagged significant adverse effects, but that's not the same as confirmed human safety

12, 26, 47 Among the claudin family, claudin-2 is unique because it is expressed predominantly in epithelia known to be relatively less tight

Both alcohol and isoniazid induce CYP2E1 and affect APAP-induced ALI by increasing NAPQI, the hepatotoxic metabolite of APAP, indicating that CYP2E1 may be the major P450 contributing to conversion of APAP to NAPQI (Zand et al., 1993

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They have no added refined sugar, our gummies are sweetened with chicory root, a prebiotic fiber that supports gut health without causing sugar spikes